Cart
sales@molnova.com
GSK 690
CAS No. 2101305-84-2
GSK 690( GSK690 )
Catalog No. M13334 CAS No. 2101305-84-2
GSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGSK 690
-
NoteResearch use only, not for human use.
-
Brief DescriptionGSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
-
DescriptionGSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
-
In VitroGSK690 (1-10μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells) and 10?μM GSK690 for RH30 cells.GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
-
In Vivo——
-
SynonymsGSK690
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorHistone Demethylase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2101305-84-2
-
Formula Weight369.468
-
Molecular FormulaC24H23N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
-
Chemical Name(R)-4-[5-(Pyrrolidin-3-ylmethoxy)-2-p-tolyl-pyridin-3-yl]-benzonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Mould DP, et al. J Med Chem. 2017 Sep 11. doi: 10.1021/acs.jmedchem.7b00462.
2. Mould DP, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4755-4759.
3. McGrath JP, et al. Cancer Res. 2016 Apr 1;76(7):1975-88.
molnova catalog
related products
-
SD49-7
SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 μM.
-
T-3775440 hydrochlor...
A novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
-
GSK-467
GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM.
